the ives of the mrff 2022 multiple sclerosis research grant opportunity are to support medical research and medical innovation projects that: stream 1: promote australian involvement in international collaborative investigator-initiated clinical trials testing the effectiveness of vaccines for prevention of latent epstein-barr virus infection through the establishment and coordination of clinical trials site/s in australia stream 2: clinical trials to accelerate the development or repurposing of therapeutic candidates (including antivirals) to treat epstein-barr virus for the purpose of preventing or treating conditions such as multiple sclerosis stream 3: characterise how immune responses to viral infections trigger autoimmune diseases including multiple sclerosis in some individuals to generate knowledge that supports risk stratification so identified individuals can employ strategies to reduce their chance of developing autoimmune disease stream 4: develop, implement and/or validate approaches for early intervention in individuals recovering from viral infections that aim to reduce the risk and/or severity of the long-term autoimmune consequences, including multiple sclerosis.